Plasma Exosomes Loaded pH-Responsive Carboxymethylcellulose Hydrogel Promotes Wound Repair by Activating the Vascular Endothelial Growth Factor Signaling Pathway in Type 1 Diabetic Mice.

Abstract

Chronic wound healing plagues thousands of diabetic patients and brings social and economic burdens. Plasma exosomes (P-Exos), regarded as nanosized therapeutic agents, have shown therapeutic efficacy in promoting diabetic wound healing. The present work prepared the P-Exos-loaded pH-responsive carboxymethylcellulose (P-Exos-loaded CMC) hydrogel to investigate its ability to accelerate diabetic wound healing and to explore its underlying mechanisms. The results showed that the P-Exos-loaded CMC hydrogel was an effective therapeutic agent for accelerating diabetic wound repair. It promoted the local wound healing process in diabetic type 1 mice and enhanced angiogenesis and re-epithelialization via activating angiogenesis-related pathways mediated by vascular endothelial growth factor (VEGF).

• Authors: Lijuan Huang, Yijie Shi, Mengdie Li, Tao Wang, Liang Zhao
• Journal: Journal of biomedical nanotechnology (J Biomed Nanotechnol) Vol. 17 Issue 10 Pg. 2021-2033 (Oct 01 2021) ISSN: 1550-7033 [Print] United States
• PMID: 34706802 (Publication Type: Journal Article)

Chemical References

• Hydrogels
• Vascular Endothelial Growth Factor A
• Carboxymethylcellulose Sodium

Topics

• Animals
• Carboxymethylcellulose Sodium
• Diabetes Mellitus, Experimental (drug therapy)
• Diabetes Mellitus, Type 1
• Exosomes
• Hydrogels
• Hydrogen-Ion Concentration
• Mice
• Signal Transduction
• Vascular Endothelial Growth Factor A
• Wound Healing