Abstract | BACKGROUND: OBJECTIVES: METHODS: Medical charts of EGPA patients treated with mepolizumab were retrospectively reviewed by the authors to describe demographics, clinical characteristics, steroid dose at the initiation of mepolizumab and during follow-up, flares, disease activity, damage accrual and laboratory results. RESULTS AND CONCLUSIONS: Among 56 patients with EGPA regularly controlled at our department, 11 patients were treated with mepolizumab because of corticodependence and unsatisfactory disease control. The mean time of treatment was 38 months (range: 3-66 months). Patients with persistent symptoms improved their asthma control, but 3 of them persisted with recurrent ENT symptoms in spite of treatment with mepolizumab. None of the patients developed vasculitic manifestations (cutaneous, neurological, gastrointestinal, renal) during treatment. All patients achieved a Birmingham Vasculitis Activity Score (BVAS) of 0 points at 12 months or earlier. In general, patients reduced the number of flares, which tended to be milder, and all related to asthma or ENT manifestations. The improvement in disease activity allowed notable glucocorticoid tapering.
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Authors | Roberto Ríos-Garcés, Sergio Prieto-González, José Hernández-Rodríguez, Ebymar Arismendi, Isam Alobid, Alessandra E Penatti, María C Cid, Georgina Espígol-Frigolé |
Journal | European journal of internal medicine
(Eur J Intern Med)
Vol. 95
Pg. 61-66
(Jan 2022)
ISSN: 1879-0828 [Electronic] Netherlands |
PMID | 34535374
(Publication Type: Journal Article)
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Copyright | Copyright © 2021. Published by Elsevier B.V. |
Chemical References |
- Antibodies, Monoclonal, Humanized
- mepolizumab
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Topics |
- Antibodies, Monoclonal, Humanized
(therapeutic use)
- Churg-Strauss Syndrome
(drug therapy)
- Granulomatosis with Polyangiitis
(complications, drug therapy)
- Humans
- Retrospective Studies
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