High fibular osteotomy ameliorates medial compartment knee osteoarthritis in a rabbit model.

Abstract

Knee osteoarthritis (KOA) is a common and severe disease characterized by articular cartilage degeneration, subchondral bone remodeling and inflammation. The purpose of this study was to investigate the therapeutic effects of high fibular osteotomy (HFO) in a KOA rabbit model and to examine the molecular mechanisms involved in medial compartment KOA protective effects. Our data showed that HFO delayed the progression of articular cartilage damage and suppressed subchondral bone remodeling in destabilization of the medial meniscus (DMM)-induced KOA model. HFO also decreased MMP-1, MMP-3, MMP-13 and ADAMTS-5 expression, and increased Col2 and aggrecan expression. In parallel, HFO attenuated the expression of IL-1β, IL-6 and TNF-α. Furthermore, HFO suppressed DMM-mediated NFκB activation, which suggested that the molecular mechanism underlying the protective effect of HFO in medial compartment KOA may be related to the NFκB signaling pathway. Collectively, our data indicated that HFO may be a therapeutic approach to treating medial compartment KOA.

• Authors: Feihua Yan, Xujun Zhao, Shisheng Duan, Aini Maimaiti, Yong Qi, Maozhao Li, Muteli Maimaiti, Wenqiang Li
• Journal: Journal of biomechanics (J Biomech) Vol. 128 Pg. 110734 (11 09 2021) ISSN: 1873-2380 [Electronic] United States
• PMID: 34509913 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.

Topics

• Animals
• Cartilage, Articular
• Disease Models, Animal
• Knee Joint
• Menisci, Tibial
• Osteoarthritis, Knee
• Osteotomy
• Rabbits