68Ga-Exendin-4 PET/CT Differentiates Insulinoma From Accessory Spleen in a Patient Presenting Indeterminate MRI and 68Ga-DOTATATE PET/CT Findings.

Abstract

ABSTRACT:

A 55-year-old woman with endogenous hyperinsulinemia hypoglycemia was clinically diagnosed with insulinoma. Contrast-enhanced MRI revealed an inconclusive hypointense lesion in the pancreatic tail, and the enhancement pattern does not support the diagnosis of insulinoma. 68Ga-DOTATATE PET/CT showed intense radioactivity in this nodule, similar to the radioactivity of the adjacent spleen. Therefore, the diagnosis of accessory spleen cannot be excluded. Follow-up with 68Ga-exendin-4 PET/CT also showed intense uptake in this nodule, but no significant uptake in the spleen was observed at this time. Therefore, the insulinoma was unmasked from the spleen, excluding the diagnosis of accessory spleen, and allowing curative surgery.

• Authors: Yizhen Pang, Tinghua Meng, Qihang Shang, Zheng Chen, Haojun Chen
• Journal: Clinical nuclear medicine (Clin Nucl Med) Vol. 47 Issue 3 Pg. 265-267 (Mar 01 2022) ISSN: 1536-0229 [Electronic] United States
• PMID: 34507334 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.

Chemical References

• Organometallic Compounds
• copper dotatate CU-64
• Exenatide

Topics

• Exenatide
• Female
• Humans
• Insulinoma (diagnostic imaging)
• Magnetic Resonance Imaging
• Middle Aged
• Organometallic Compounds
• Pancreatic Neoplasms (diagnostic imaging)
• Positron Emission Tomography Computed Tomography
• Positron-Emission Tomography
• Radionuclide Imaging
• Spleen (diagnostic imaging)