Abstract | BACKGROUND: AIM: To investigate late lumen loss as assessed via quantitative coronary angiography (QCA) and optical coherence tomography (OCT) in patients with acute coronary syndrome treated with Magmaris stents or permanent, everolimus-eluting metallic Xience stents. METHODS AND RESULTS: This PRAGUE-22 study was a two-centre, investigator-initiated, randomized study. Fifty patients were randomized based on the inclusion criteria for acute coronary syndrome and the anatomical suitability to receive Magmaris or Xience stents. The patient characteristics did not differ between the Magmaris group (n = 25) and Xience group (n = 25). The mean ages were 57.0 ± 10.5 vs. 55.5 ± 9.2 years (p = 0.541) and the total implanted stent length was 24.6 ± 10.7 mm vs. 27.6 ± 11.1 mm (p = 0.368), respectively. Four clinical events occurred in the Magmaris group and one in the Xience group during 12 months of follow-up. The extent of late lumen loss (assessed via QCA) at 12 months was greater in the Magmaris group than in the Xience group (0.54 ± 0.70 vs. 0.11 ± 0.37 mm; p = 0.029). The late lumen loss diameter (measured via OCT) in the Magmaris group was also significantly larger than that in the Xience group (0.59 ± 0.37 vs. 0.22 ± 0.20 mm; p = 0.01). CONCLUSION: TRIAL REGISTRATION: ISRCTN89434356.
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Authors | Petr Toušek, Tomáš Lazarák, Ivo Varvařovský, Markéta Nováčková, Marek Neuberg, Viktor Kočka |
Journal | Cardiovascular drugs and therapy
(Cardiovasc Drugs Ther)
Vol. 36
Issue 6
Pg. 1129-1136
(12 2022)
ISSN: 1573-7241 [Electronic] United States |
PMID | 34505954
(Publication Type: Randomized Controlled Trial, Journal Article)
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Copyright | © 2021. The Author(s). |
Chemical References |
- Everolimus
- Sirolimus
- Magnesium
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Topics |
- Humans
- Everolimus
(adverse effects)
- Sirolimus
- Drug-Eluting Stents
- Magnesium
- Absorbable Implants
- Acute Coronary Syndrome
(diagnostic imaging, therapy)
- Coronary Angiography
- Treatment Outcome
- Percutaneous Coronary Intervention
(adverse effects, methods)
- Coronary Artery Disease
(therapy)
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