sLOX-1: A Molecule for Evaluating the Prognosis of Recurrent Ischemic Stroke.

Abstract

Several clinical parameters and biomarkers have been proposed as prognostic markers for stroke. However, it has not been clarified whether the risk factors affecting the prognosis of patients with recurrent and first-ever stroke are similar. In this study, we aimed to explore the relationship between soluble lectin-like oxidized low-density lipoprotein receptor 1 (sLOX-1) levels and the prediction of the functional outcome in patients with recurrent and first-ever stroke. A total of 266 patients with recurrent and first-ever stroke, who underwent follow-up for 3 months, were included in this study. Plasma samples were collected within 24 h after onset. The results showed that biomarkers for the prognosis of patients with recurrent stroke were different from that of those with first-ever stroke. sLOX-1 levels were correlated with modified Rankin Scale scores of patients with recurrent stroke alone (r = 0.3232, p = 0.001). sLOX-1 levels were also associated with an increased risk of unfavorable outcomes in patients with recurrent stroke with an adjusted odds ratio of 1.489 (95% confidence interval, 1.204-1.842, p < 0.0001). Combining the risk factors showed greater accuracy for prognosis, yielding a sensitivity of 93.2% and a specificity of 75%, with an area under the curve of 0.916, evaluated by the receiver operating characteristic curve. These findings suggest that the diagnosis and prognosis are different between patients with recurrent stroke and those with first-ever stroke, and sLOX-1 level is an independent prognostic marker in patients with recurrent stroke.

• Authors: Yangmin Zheng, Yuyou Huang, Lingzhi Li, Pingping Wang, Rongliang Wang, Zhen Tao, Junfen Fan, Ziping Han, Fangfang Li, Haiping Zhao, Fangfang Zhao, Feng Yan, Yumei Liu, Yumin Luo
• Journal: Neural plasticity (Neural Plast) Vol. 2021 Pg. 6718184 ( 2021) ISSN: 1687-5443 [Electronic] United States
• PMID: 34497641 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2021 Yangmin Zheng et al.

Chemical References

• Biomarkers
• OLR1 protein, human
• Scavenger Receptors, Class E

Topics

• Aged
• Biomarkers (blood)
• Brain Ischemia (blood, diagnostic imaging)
• Female
• Humans
• Ischemic Stroke (blood, diagnostic imaging)
• Male
• Middle Aged
• Prognosis
• Recurrence
• Risk Factors
• Scavenger Receptors, Class E (blood)
• Solubility