The effect of oral or nasal feeding with Chinese
patent medicine on
hypertensive intracerebral hemorrhage was systematically evaluated by using the method of network Meta-analysis. Four Chinese databases(CNKI, VIP, Wanfang, CBM), three English databases(Medline, EMbase, Cochrane Library) and ClinicalTrials.gov were retrieved through computers. According to the inclusion criteria and exclusion criteria, randomized controlled trials(RCTs) of Chinese
patent medicine combined with Western medicine in the treatment of
hypertensive intracerebral hemorrhage were screened out according to the inclusion criteria and exclusion criteria. The Cochrane bias risk assessment tool was used to evaluate the quality of the included studies, and Stata 16.0 software was used to analyze the outcome indicators. A total of 3 888 literatures were retrieved, and 30 studies involving 6 kinds of Chinese
patent medicines were finally included. The total sample size was 2 758 cases, including 1 401 cases in the treatment group and 1 357 cases in the control group. According to the results of network Meta-analysis,(1)in terms of improving the degree of nerve function defect, the order of Chinese
patent medicines was conventional Western medicine combined with Xiaoyukang Capsules>combined with
Tongxinluo Capsules>combined with Naoxuekang Oral Liquid>combined with Naoxueshu Oral Liquid>combined with Angong
Niuhuang Pills>conventional Western medicine;(2)in terms of reducing the amount of residual cerebral
hematoma, the order of Chinese
patent medicines was conventional Western medicine combined with Naoxueshu Oral Liquid>combined Xiaoyukang Capsules>combined Naoxuekang Oral Liquid>conventional Western medicine;(3)in terms of improving ability of daily living, the order of Chinese
patent medicines was conventional Western medicine combined with Shenzhi Huoxue Capsules>combined with Angong
Niuhuang Pills>combined with Naoxueshu Oral Liquid>conventional Western medicine;(4)in terms of improving total effective rate, the order of Chinese
patent medicines was conventional Western medicine combined with Naoxueshu Oral Liquid>combined with Xiaoyukang Capsules>combined with Angong
Niuhuang Pills=combined with Naoxuekang Oral Liquid>combined
Tongxinluo Capsules>conventional Western medicine treatment. The results showed that in addition to conventional Western medicine
therapy, the combined use with Chinese
patent medicine can improve the clinical efficacy in the treatment of
hypertensive intracerebral hemorrhage. However, due to the differences in the number and quality of various Chinese
patent medicines included in the studies, and the lack of direct comparison of Chinese
patent medicines, the ranking results still need to be verified by multi center, large-sample-size randomized double-blind trials in the future, so as to provide more reliable evidence support for clinical drug use.