[Effect of brovincamine fumarate on cerebral ischemia acutely induced by BLCL in SHRSR].

Abstract

The present study was designed to clarify the effect of brovincamine fumarate (BV 26-723: BV) on the degree of cerebral ischemia acutely induced by bilateral common carotid artery ligation (BLCL) in stroke-resistant spontaneously hypertensive rats (SHRSR). BV was administered to SHRSR by intraperitoneal infusion (I.P.) of 30 mg/kg (BV 30 mg/kg group), 60 mg/kg (BV 60 mg/kg group) and 0.9% saline was similarly injected to SHRSR (control group) before and immediately after BLCL. Cerebral blood flow (rCBF) in the thalamus was measured by hydrogen clearance technique before and until 3 hr of BLCL periodically. The brain metabolites (ATP, lactate, pyruvate) were determined by the enzymatic method and the brain water content was measured by freeze-dry method 3 hr after BLCL. The histopathological changes in brain vessels were observed by scanning electron microscopy (SEM) 3 hr after BLCL. The rCBF of three groups were identical before BLCL. However, the rCBF of BV 30 mg/kg group was statistically higher than in control group until 2 hr after BLCL, and that of BV 60 mg/kg group was significantly higher even 3 hr after BLCL. In measurements of the brain metabolites after BLCL, ATP and pyruvate levels in both the BV 30 mg/kg and 60 mg/kg groups were statistically higher than the control group. And brain lactate concentrations in both the BV 30 mg/kg and 60 mg/kg groups were significantly lower than the control group. The brain water content of BV 30 mg/kg and 60 mg/kg groups were significantly lower then the control group after BLCL.(ABSTRACT TRUNCATED AT 250 WORDS)

• Authors: S Suzuki, H Memezawa, Y Katayama, J Shimizu, S Sugimoto, A Nagazumi, A Terashi
• Journal: No to shinkei = Brain and nerve (No To Shinkei) Vol. 39 Issue 12 Pg. 1117-24 (Dec 1987) ISSN: 0006-8969 [Print] Japan
• PMID: 3446248 (Publication Type: English Abstract, Journal Article)

Chemical References

• Vinca Alkaloids
• Vincamine
• 11-bromovincamine

Topics

• Acute Disease
• Animals
• Brain (metabolism)
• Brain Edema (metabolism)
• Brain Ischemia (drug therapy, etiology, pathology)
• Carotid Arteries (surgery)
• Cerebrovascular Circulation (drug effects)
• Endothelium, Vascular (drug effects, pathology)
• Ligation
• Male
• Rats
• Rats, Inbred SHR
• Vinca Alkaloids (therapeutic use)
• Vincamine (analogs & derivatives, therapeutic use)