Abstract |
Macrophages have high plasticity and heterogeneity, and can suppress or mediate inflammation, depending on their cytokine secretion and phenotype. Regulating macrophage polarization into its M2 phenotype has a remarkable effect on inflammatory inhibition, inducing the regeneration of injured tissues. Here, we synthesized two heptamannosylated β- cyclodextrin derivatives (CD-Man7 and C3-CD-Man7) and demonstrated that their multivalent mannose ligands could induce M2 macrophage polarization to accelerate wound healing. Unlike hydrophilic CD-Man7, amphiphilic C3-CD-Man7 can self-assemble to form nanoparticles (CD-Man-NPs) in aqueous solution. Further, in vitro results confirmed that multivalent mannose ligands of either CD-Man7 or CD-Man-NPs stimulated RAW264.7 macrophages to differentiate into the M2 phenotype, which promoted fibroblast migration via a paracrine mechanism. In vivo results confirmed that both CD-Man7 and CD-Man-NPs reduced the inflammatory response in wound tissue and accelerated wound healing. The present study demonstrates multivalent effects of CD-Man7 and CD-Man-NPs on M2 macrophage polarization, indicating the therapeutic potential of these β- cyclodextrin glycoconjugates in the treatment of inflammatory diseases and wound healing.
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Authors | Yuan-Ning Zhang, Ruibo Zhao, Jie Cao, Bowen Chen, Dandan Luo, Jiaju Lu, Muhammed Zubair Iqbal, Quan Zhang, Xiangdong Kong |
Journal | Colloids and surfaces. B, Biointerfaces
(Colloids Surf B Biointerfaces)
Vol. 208
Pg. 112071
(Dec 2021)
ISSN: 1873-4367 [Electronic] Netherlands |
PMID | 34461486
(Publication Type: Journal Article)
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Copyright | Copyright © 2021 Elsevier B.V. All rights reserved. |
Chemical References |
- Cytokines
- beta-Cyclodextrins
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Topics |
- Cytokines
- Humans
- Macrophage Activation
- Macrophages
- Wound Healing
- beta-Cyclodextrins
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