Abstract |
Background: Osteoarthritis (OA) in the anterior cruciate ligament (ACL)-deficient knee is seen in approximately 50% of affected patients. Possible causes include biochemical or biomechanical changes. Purpose: We sought to study the correlation between inflammatory cytokines and chondral damage in ACL-deficient knees. Methods: Seventy-six male patients who underwent ACL reconstruction were enrolled in a cross-sectional study. Synovial fluid was aspirated before surgery and analyzed for levels of the inflammatory cytokines tumor necrosis factor-α, interleukin-1 (IL-1), and interleukin-6 (IL-6). At the time of ACL reconstruction, the severity of chondral damage was documented as described by the Outerbridge classification. Results: Patients with grade 2 or higher chondral damage were observed to have elevated IL-6 levels when compared to patients who had no chondral damage. Interleukin-6 levels had no correlation with the duration of injury. Conclusion: Elevated levels of IL-6 in synovial fluid were associated with chondral damage in ACL-deficient knees. Further study is warranted to determine whether inflammatory cytokines contribute to the development of OA of the knee after ACL injury.
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Authors | Ravi Gupta, Anil Kapoor, Sourabh Khatri, Dinesh Sandal, Gladson David Masih |
Journal | HSS journal : the musculoskeletal journal of Hospital for Special Surgery
(HSS J)
Vol. 17
Issue 2
Pg. 145-149
(Jul 2021)
ISSN: 1556-3316 [Print] United States |
PMID | 34421423
(Publication Type: Journal Article)
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Copyright | © The Author(s) 2021. |