The
analgesic efficacy of
fendosal, a new
nonsteroidal anti-inflammatory agent structurally related to
salicylic acid, was compared with that of
aspirin and placebo in 100 patients with postpartum uterine
pain in a single oral dose, parallel, stratified, randomized, double-blind design. With 650 mg
aspirin and with 200 or 400 mg
fendosal, but not with 100 mg,
analgesic effects, as measured subjectively by mean
pain intensity scores, began within 1 hr and had similar time-effect patterns for the first 4 or 5 hr. Thereafter with the 2 higher doses of
fendosal analgesia contimued to increase, reaching a peak at 6 hr (p less than 0.05) and persisting beyond 7 hr (p less than 0.01), whereas there was
no aspirin analgesia after the fifth hour. With 100 mg
fendosal time of onset tended to be delayed 2 hr or more, and duration was short. The most effective treatment (largest mean 7-hr sum of
pain intensity difference [SPID] scores) was 400 mg
fendosal (p less than 0.01); 200 mg
fendosal was rated second (p less than 0.01), 650 mg
aspirin, third (p less than 0.05), 100 mg
fendosal, fourth, and placebo, fifth. There was no significant side effects. These results demonstrate the efficacy of single doses of
fendosal as well as the dose-dependent magnitude and time course of effects on postpartum uterine
pain.