Abstract | PURPOSE: Individuals with diabetes/stress hyperglycemia carry an increased risk for adverse clinical outcome in case of SARS-CoV-2 infection. The purpose of this study was to evaluate whether this risk is, at least in part, modulated by an increase of thromboembolic complications. METHODS: We prospectively followed 180 hospitalized patients with confirmed COVID-19 pneumonia admitted to the Internal Medicine Units of San Raffaele Hospital. Data from 11 out of 180 patients were considered incomplete and excluded from the analysis. We analysed inflammation, tissue damage biomarkers, hemostatic parameters, thrombotic events ( TEs) and clinical outcome according to the presence of diabetes/stress hyperglycemia. RESULTS: Among 169 patients, 51 (30.2%) had diabetes/stress hyperglycemia. Diabetes/stress hyperglycemia and fasting blood glucose (FBG) were associated with increased inflammation and tissue damage circulating markers, higher D-dimer levels, increased prothrombin time and lower antithrombin III activity. Forty-eight venous and 10 arterial TEs were identified in 49 (29%) patients. Diabetes/stress hyperglycemia (HR 2.71, p = 0.001), fasting blood glucose (HR 4.32, p < 0.001) and glucose variability (HR 1.6, p < 0.009) were all associated with an increased risk of thromboembolic complication. TEs significantly increased the risk for an adverse clinical outcome only in the presence of diabetes/stress hyperglycemia (HR 3.05, p = 0.010) or fasting blood glucose ≥7 mmol/L (HR 3.07, p = 0.015). CONCLUSIONS:
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Authors | Stefania L Calvisi, Giuseppe A Ramirez, Marina Scavini, Valentina Da Prat, Giuseppe Di Lucca, Andrea Laurenzi, Gabriele Gallina, Ludovica Cavallo, Giorgia Borio, Federica Farolfi, Maria Pascali, Jacopo Castellani, Vito Lampasona, Armando D'Angelo, Giovanni Landoni, Fabio Ciceri, Patrizia Rovere Querini, Moreno Tresoldi, Lorenzo Piemonti |
Journal | Metabolism: clinical and experimental
(Metabolism)
Vol. 123
Pg. 154845
(10 2021)
ISSN: 1532-8600 [Electronic] United States |
PMID | 34364927
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2021 Elsevier Inc. All rights reserved. |
Topics |
- Aged
- Aged, 80 and over
- COVID-19
(complications, diagnosis, epidemiology, therapy)
- Diabetes Complications
(diagnosis, epidemiology, therapy)
- Diabetes Mellitus
(blood, diagnosis, epidemiology, therapy)
- Female
- Follow-Up Studies
- Hospitalization
(statistics & numerical data)
- Humans
- Hyperglycemia
(diagnosis, epidemiology, etiology, therapy)
- Inflammation
(complications, diagnosis, epidemiology, therapy)
- Italy
(epidemiology)
- Male
- Middle Aged
- Mortality
- Prognosis
- Risk Factors
- Stress, Psychological
(complications, diagnosis, epidemiology)
- Thromboembolism
(diagnosis, epidemiology, etiology)
- Treatment Outcome
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