Abstract | BACKGROUND: Elevated epidermal interleukin (IL)-36 expression distinguishes psoriasis from eczematous dermatitis, but other psoriasiform dermatitides (PDs) have not been thoroughly investigated for IL-36 expression. In this study, we assess the IL-36 staining pattern (IL36-SP) in psoriasis variants and other PDs including lichen simplex chronicus (LSC), prurigo nodularis (PN), lichen planus (LP), tinea, pityriasis rubra pilaris (PRP), mycosis fungoides (MF), pemphigus foliaceus (PF), acute generalized exanthematous pustulosis (AGEP), impetigo ( IMP), and syphilis (SY). METHODS: IL-36 immunostaining was performed on 307 cases of psoriasis and various PDs. IL36-SP in the upper epidermis was graded on a scale of 0-4. RESULTS: High IL36-SP occurred in all variants of psoriasis, as well as in AGEP, PRP, PN, tinea, IMP, and LP (P > 0.05). SY, PF, LSC, and MF showed a lower IL36-SP (P ≤ 0.05) compared with psoriasis. CONCLUSION: All variants of psoriasis exhibit high IL36-SP. IL-36 staining can assist in differentiating MF, PF, SY, and LSC from psoriasis, particularly MF and LSC, which have consistent low IL-36 expression. AGEP, PRP, tinea, IMP, PN, and LP exhibit high IL-36 expression similar to psoriasis, indicating Th17 activation in these diseases.
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Authors | Terese Monette Aquino, Mary Grace Calvarido, Jeffrey P North |
Journal | Journal of cutaneous pathology
(J Cutan Pathol)
Vol. 49
Issue 2
Pg. 123-132
(Feb 2022)
ISSN: 1600-0560 [Electronic] United States |
PMID | 34346097
(Publication Type: Journal Article)
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Copyright | © 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
Chemical References |
- Interleukin-1
- interleukin 36, human
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Epidermis
(metabolism, pathology)
- Female
- Humans
- Interleukin-1
(metabolism)
- Male
- Middle Aged
- Psoriasis
(metabolism, pathology)
- Skin Diseases
(metabolism, pathology)
- Young Adult
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