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Is NPH associated with fewer adverse events than analog basal insulin for adults with T2D?

Abstract
NO. Insulin glargine may lead to less patient-reported, symptomatic, and nocturnal hypoglycemia, although overall, there may not be a difference in the risk for severe hypoglycemia orhypoglycemiarelated emergency department (ED) visits and hospitalizations (strength of recommendation [SOR]: B, systematic review of randomized controlled trials [RCTs], individual RCTs, and observational study).
AuthorsCorey Lyon, Swetha Iruku, Molly Hoss, Kristen DeSanto, Richard Guthmann
JournalThe Journal of family practice (J Fam Pract) Vol. 70 Issue 4 Pg. E5-E6 (05 2021) ISSN: 1533-7294 [Electronic] United States
PMID34339367 (Publication Type: Comparative Study, Journal Article, Meta-Analysis, Systematic Review)
Chemical References
  • Insulin Glargine
  • Insulin, Isophane
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Diabetes Mellitus, Type 2 (drug therapy)
  • Female
  • Humans
  • Hypoglycemia (chemically induced)
  • Insulin Glargine (adverse effects, therapeutic use)
  • Insulin, Isophane (adverse effects, therapeutic use)
  • Male
  • Middle Aged
  • Treatment Outcome

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