Abstract | OBJECTIVES: METHODS: A narrative qualitative review RESULTS: Dose-response relationships of antidepressants such as selective serotonin reuptake inhibitors ( SSRIs) are not linear. They may be bell-shaped, with efficacy initially increasing with an increase in dose but decreasing when the dose is increased beyond a certain point. Despite using international diagnostic criteria, uncertainty remains on whether operationally diagnosed depression is latent bipolar I depression, latent bipolar II depression, or true depression. Furthermore, operationally diagnosed bipolar II depression may be latent bipolar I depression, true bipolar II depression, or depression with false hypomanic episodes. Manic/hypomanic switches are most likely to occur in patients receiving tricyclic antidepressants, followed by those receiving serotonin and noradrenaline reuptake inhibitors and SSRIs, in that order. Also, these switches are most likely to occur in patients with bipolar I depression, followed by those with bipolar II depression and true depression, in that order. CONCLUSIONS:
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Authors | Takeshi Terao |
Journal | Brain and behavior
(Brain Behav)
Vol. 11
Issue 8
Pg. e2308
(08 2021)
ISSN: 2162-3279 [Electronic] United States |
PMID | 34327873
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Copyright | © 2021 The Authors. Brain and Behavior published by Wiley Periodicals LLC. |
Chemical References |
- Antidepressive Agents
- Antidepressive Agents, Tricyclic
- Serotonin Uptake Inhibitors
- Serotonin
|
Topics |
- Antidepressive Agents
(adverse effects)
- Antidepressive Agents, Tricyclic
(therapeutic use)
- Bipolar Disorder
(drug therapy)
- Depression
(drug therapy)
- Humans
- Serotonin
- Selective Serotonin Reuptake Inhibitors
(adverse effects)
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