ChAdOx1 nCoV-19 protection against SARS-CoV-2 in rhesus macaque and ferret challenge models.

Abstract

Vaccines against SARS-CoV-2 are urgently required, but early development of vaccines against SARS-CoV-1 resulted in enhanced disease after vaccination. Careful assessment of this phenomena is warranted for vaccine development against SARS CoV-2. Here we report detailed immune profiling after ChAdOx1 nCoV-19 (AZD1222) and subsequent high dose challenge in two animal models of SARS-CoV-2 mediated disease. We demonstrate in rhesus macaques the lung pathology caused by SARS-CoV-2 mediated pneumonia is reduced by prior vaccination with ChAdOx1 nCoV-19 which induced neutralising antibody responses after a single intramuscular administration. In a second animal model, ferrets, ChAdOx1 nCoV-19 reduced both virus shedding and lung pathology. Antibody titre were boosted by a second dose. Data from these challenge models on the absence of enhanced disease and the detailed immune profiling, support the continued clinical evaluation of ChAdOx1 nCoV-19.

• Authors: Teresa Lambe, Alexandra J Spencer, Kelly M Thomas, Karen E Gooch, Stephen Thomas, Andrew D White, Holly E Humphries, Daniel Wright, Sandra Belij-Rammerstorfer, Nazia Thakur, Carina Conceicao, Robert Watson, Leonie Alden, Lauren Allen, Marilyn Aram, Kevin R Bewley, Emily Brunt, Phillip Brown, Breeze E Cavell, Rebecca Cobb, Susan A Fotheringham, Ciaran Gilbride, Debbie J Harris, Catherine M K Ho, Laura Hunter, Chelsea L Kennard, Stephanie Leung, Vanessa Lucas, Didier Ngabo, Kathryn A Ryan, Hannah Sharpe, Charlotte Sarfas, Laura Sibley, Gillian S Slack, Marta Ulaszewska, Nadina Wand, Nathan R Wiblin, Fergus V Gleeson, Dalan Bailey, Sally Sharpe, Sue Charlton, Francisco J Salguero, Miles W Carroll, Sarah C Gilbert
• Journal: Communications biology (Commun Biol) Vol. 4 Issue 1 Pg. 915 (07 26 2021) ISSN: 2399-3642 [Electronic] England
• PMID: 34312487 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2021. The Author(s).

Chemical References

• Antibodies, Neutralizing
• COVID-19 Vaccines
• ChAdOx1 nCoV-19

Topics

• Animals
• Antibodies, Neutralizing (immunology)
• COVID-19 Vaccines (immunology)
• ChAdOx1 nCoV-19
• Ferrets
• Macaca mulatta
• SARS-CoV-2 (immunology)