Case Report: PD-1 Blockade Combined Autologous Hematopoietic Stem Cell Transplantation With Modified BEAM Regimen Containing High-Dose Cytarabine to Treat R/R Hodgkin's Lymphoma.

Abstract

The emergence of new drugs has provided additional options in the treatment of relapsed and refractory (R/R) Hodgkin's lymphoma (HL). However, the use of autologous stem cell transplantation (ASCT) has not been completely replaced in this setting. The use of anti-programmed death-1 (PD-1) antibody bridging to ASCT and as maintenance after transplantation is a novel approach in HL treatment. In this case, we report that PD-1 monoclonal antibody (mAb) plus ASCT with modified BEAM regimen (carmustine + etoposide + cytarabine + melphalan) containing high-dose cytarabine to treat R/R HL may represent a promising regimen in this difficult-to-treat setting.

• Authors: Xiaoqi Wang, Kaniel Cassady, Zhongmin Zou, Xi Zhang, Yimei Feng
• Journal: Frontiers in medicine (Front Med (Lausanne)) Vol. 8 Pg. 693023 ( 2021) ISSN: 2296-858X [Print] Switzerland
• PMID: 34307420 (Publication Type: Case Reports)
• Copyright: Copyright © 2021 Wang, Cassady, Zou, Zhang and Feng.