Intraventricular administration of l-kynurenine and kynuramine facilitates lordosis in the female rat.

Abstract

Intraventricular administration of the tryptophan metabolites l-kynurenine (2-32 micrograms) and kynuramine (0.064-8 micrograms) facilitated lordosis behavior in estrogen-primed ovariectomized rats. The facilitatory effects of these drugs were not attenuated by pretreatment with the progesterone antagonist RU 38486, indicating that the effects were not mediated by release of adrenal progesterone. It is suggested that l-kynurenine and kynuramine may serve a physiological role in the modulation of female sexual behavior.

• Authors: S D Mendelson, N Lee, B B Gorzalka
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 142 Issue 3 Pg. 447-51 (Oct 27 1987) ISSN: 0014-2999 [Print] Netherlands
• PMID: 3428356 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Estrenes
• Glucocorticoids
• Propiophenones
• Mifepristone
• Kynurenine
• Kynuramine
• Estradiol

Topics

• Animals
• Estradiol (pharmacology)
• Estrenes (pharmacology)
• Female
• Glucocorticoids (antagonists & inhibitors)
• Injections, Intraventricular
• Kynuramine (administration & dosage, pharmacology)
• Kynurenine (administration & dosage, pharmacology)
• Mifepristone
• Propiophenones (pharmacology)
• Rats
• Sexual Behavior, Animal (drug effects)