Recovery of deepening of the upper eyelid sulcus after switching from prostaglandin FP receptor agonists to EP2 receptor agonist: a 3-month prospective analysis.

Abstract

PURPOSE:

To examine the effect of switching from a prostanoid FP receptor agonists to EP2 receptor agonist (omidenepag isopropyl) on the deepening of the upper eyelid sulcus (DUES) and intraocular pressure (IOP) in Japanese glaucoma patients over 3 months post treatment.

STUDY DESIGN:

Prospective observational study.

METHODS:

Patients with glaucoma who received FP receptor agonists treatment and had complained of DUES-related reduction in quality of life were included. Their FP receptor agonists was switched to omidenepag isopropyl without a drug holiday. At baseline and 1 and 3 months post-switch, photographs were taken and the changes in DUES were assessed by three independent observers. IOP and adverse events were also assessed.

RESULTS:

The study included 23 eyes of 23 patients (6 men, 17 women; average age, 60.6 years). After switching, DUES improved in 12 eyes at 1 month and in 16 eyes at 3 months; eyes in the remaining patients showed no worsening of the condition. The mean IOP before switching was 15.3 ± 3.3 mmHg (95% confidence interval 13.9-16.7 mmHg). Following the switch, the mean IOP values were 15.6 ± 3.3 mmHg (14.1-17.0 mmHg) at 1 month and 15.5 ± 3.3 mmHg (14.1-16.9 mmHg) at 3 months (P = 1.0 at 1 month, P = 1.0 at 3 months; both adjusted by Bonferroni correction). No adverse effects were observed.

CONCLUSION:

Omidenepag isopropyl improved DUES while maintaining IOP in over 70% of Japanese patients with glaucoma who exhibited DUES caused by FP receptor agonists; the improvement was observed within 3 months after switching from FP receptor agonists.

• Authors: Rei Sakata, Takashi Fujishiro, Hitomi Saito, Natsuko Nakamura, Megumi Honjo, Shiroaki Shirato, Etsuyo Miyamoto, Yoshiaki Yamada, Makoto Aihara
• Journal: Japanese journal of ophthalmology (Jpn J Ophthalmol) Vol. 65 Issue 5 Pg. 591-597 (Sep 2021) ISSN: 1613-2246 [Electronic] Japan
• PMID: 34283308 (Publication Type: Journal Article, Observational Study)
• Copyright: © 2021. Japanese Ophthalmological Society.

Chemical References

• Antihypertensive Agents
• Ophthalmic Solutions
• Prostaglandins
• Receptors, Prostaglandin
• prostaglandin F2alpha receptor

Topics

• Antihypertensive Agents (therapeutic use)
• Eyelids
• Female
• Glaucoma, Open-Angle (diagnosis, drug therapy)
• Humans
• Intraocular Pressure
• Male
• Middle Aged
• Ophthalmic Solutions
• Prostaglandins
• Quality of Life
• Receptors, Prostaglandin