Recent advances in cell therapy for stroke.

Abstract

The last 50 years have witnessed the translation of stem cell therapy from the laboratory to the clinic for treating brain disorders, in particular stroke. From the focal stereotaxic transplantation to the minimally invasive intravenous and intraarterial delivery, stem cells display the ability to replenish injured cells and to secrete therapeutic molecules, altogether promoting brain repair. The increased stroke incidence in COVID-19 survivors poses as a new disease indication for cell therapy, owing in part to the cells' robust anti-inflammatory properties. Optimization of the cell transplant regimen will ensure the safe and effective clinical application of cell therapy in stroke and relevant neurological disorders.

• Authors: You Jeong Park, Cesar V Borlongan
• Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (J Cereb Blood Flow Metab) Vol. 41 Issue 10 Pg. 2797-2799 (10 2021) ISSN: 1559-7016 [Electronic] United States
• PMID: 34187231 (Publication Type: Journal Article)

Topics

• Animals
• Brain (pathology)
• COVID-19 (complications, diagnosis)
• Humans
• Incidence
• Regenerative Medicine (methods)
• SARS-CoV-2 (isolation & purification)
• Stem Cell Transplantation (methods)
• Stroke (etiology, pathology, therapy)