Ribeiro Baptista, Bruno, Morgane Faure, Gimbada Benny Mwenge, Capucine Morelot-Panzini, Christian Straus, Thomas Similowski, and Jésus Gonzalez-Bermejo. Feasibility of a hypoxic challenge test under
noninvasive ventilation versus
oxygen in neuromuscular patients with chronic
respiratory insufficiency. High Alt Med Biol. 22:346-350, 2021. Background: The British Thoracic Society recommendations suggest that all patients with an oxygen saturation (SpO2) <85% during a hypoxic challenge test (HCT) should receive supplemental
oxygen during air travel. However, neuromuscular patients already using ventilatory support are a specific population and
noninvasive ventilation (NIV) during a flight could be an alternative to
oxygen for
hypoxemia correction, through the augmentation of ventilation. Methods: We conducted a comparative, observational study of neuromuscular patients with chronic
respiratory failure, requiring nocturnal
mechanical ventilation, who were planning to take a flight. HCT was performed with a ventilated canopy placed over the patient's head or the patient's home
ventilator. The positive threshold value chosen for the HCT was <90% SpO2. Results: HCTs were performed on 13 adults with
neuromuscular diseases using their home
ventilator. Among them, 11 had a positive HCT. For all patients with a positive test,
hypoxemia was corrected (SpO2 to >90%) by
oxygen therapy (+9 [6-12]%, p = 0.0029). Patient's home
ventilator also significantly increased the SpO2 by 8 [7-12]% (p = 0.016). Correction of SpO2 during the HCT was not different between
oxygen and NIV. NIV was associated with a significant decrease in pressure, end tidal,
carbon dioxide (PetCO2) (-10 [-16 to -7.5] mmHg, p = 0.04). Conclusions: The performance of an adapted HCT in home-ventilated patients with a neuromuscular pathology may be useful in a personalized treatment plan for air travel. NIV can be a new alternative to
oxygen therapy for neuromuscular patients planning to take a flight.