BMY-28438 (3,7-dihydroxytropolone), a new antitumor antibiotic active against B16 melanoma. I. Production, isolation, structure and biological activity.

Abstract	A new antitumor antibiotic BMY-28438 was isolated from the cultured broth of Streptomyces tropolofaciens No. K611-97. The antibiotic showed potent cytotoxicity against cultured B16 melanoma cells and remarkable prolongation of life span of mice bearing B16 melanoma. The structure of BMY-28438 was determined as 3,7-dihydroxytropolone on the basis of spectral analyses and direct comparison with the authentic compound synthesized.
Authors	K Sugawara, M Ohbayashi, K Shimizu, M Hatori, H Kamei, M Konishi, T Oki, H Kawaguchi
Journal	The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 41 Issue 7 Pg. 862-8 (Jul 1988) ISSN: 0021-8820 [Print] England
PMID	3417559 (Publication Type: Journal Article)
Chemical References	Antibiotics, Antineoplastic Tropolone 3,7-dihydroxytropolone
Topics	Animals Antibiotics, Antineoplastic (biosynthesis, isolation & purification, pharmacology) Bacteria (drug effects) Chemical Phenomena Chemistry Fermentation Male Mice Neoplasms, Experimental (drug therapy) Streptomyces (metabolism) Tropolone (analogs & derivatives, isolation & purification, pharmacology) Tumor Cells, Cultured (drug effects)

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