Splenic Infarcts and Pulmonary Renal Syndrome in a Young Patient with Double-Positive Anti-GBM and ANCA-Associated Vasculitis.

Abstract

Double-positive disease, defined by double-seropositivity for serum anti-glomerular basement membrane (GBM) antibodies and anti-neutrophil cytoplasmic antibodies (ANCA) is a rare cause of pulmonary-renal syndrome. Here, we present an exceptional course of a 20-year-old male with seropositivity for anti-myeloperoxidase anti-neutrophil cytoplasmic antibodies and anti-GBM antibody, who presented first with renal impairment due to focal necrotizing crescentic glomerulonephritis. After receiving treatment, he presented two years later with a relapse manifesting with diffuse alveolar hemorrhage and multiple splenic infarcts. We discuss the clinical presentation patterns and treatment strategies of this entity.

• Authors: Fares T Rajah, Ali A Alhabobi, Noura M Aloudah, Ayumun I Osman, Elwaleed A Elhassan
• Journal: Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia (Saudi J Kidney Dis Transpl) 2021 Jan-Feb Vol. 32 Issue 1 Pg. 240-244 ISSN: 1319-2442 [Print] Saudi Arabia
• PMID: 34145139 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Antineutrophil Cytoplasmic
• Autoantibodies
• antiglomerular basement membrane antibody

Topics

• Antibodies, Antineutrophil Cytoplasmic (blood)
• Autoantibodies (blood)
• Glomerulonephritis (blood, complications)
• Hemorrhage (blood, complications)
• Humans
• Lung Diseases (blood, complications)
• Male
• Splenic Infarction (blood, complications)
• Young Adult