XY sex reversal syndrome in the mare: clinical and behavioral studies, H-Y phenotype.

Abstract

An inherited genetic disorder causes XY embryos of the horse to develop as mares. On the basis of our study of 38 such mares, we have identified four grades or classes of XY sex reversal according to this scheme: class I, nearly normal female, of which some are fertile; class II, female with gonadal dysgenesis, normal mullerian development; class III, intersex mare with gonadal dysgenesis, abnormal mullerian development, enlarged clitoris; class IV, virilized intersex characterized by high levels of testosterone. In general, class I and class II mares were typed H-Y antigen-negative whereas class III and class IV mares were typed H-Y antigen-positive.

• Authors: M G Kent, R N Shoffner, A Hunter, K O Elliston, W Schroder, E Tolley, S S Wachtel
• Journal: Human genetics (Hum Genet) Vol. 79 Issue 4 Pg. 321-8 (Aug 1988) ISSN: 0340-6717 [Print] Germany
• PMID: 3410457 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• H-Y Antigen

Topics

• Animals
• Behavior, Animal (physiology)
• Disorders of Sex Development (pathology, veterinary)
• Female
• Genitalia, Female (pathology)
• Gonadal Dysgenesis, Mixed (pathology, veterinary)
• H-Y Antigen (analysis)
• Horse Diseases (genetics, pathology)
• Horses (genetics)
• Male
• Pedigree
• Phenotype
• Sex Determination Analysis
• Testis (pathology)