Synthesis of pterodontic acid derivatives and the study of their anti-influenza A virus (H1N1) activity.

Abstract

Laggera pterodonta (DC.) Benth, a folk herb widely distributes in southwest China, especially in Yunnan Province, demonstrates anti-pathogenic microorganisms, anti-inflammatory, inhibition of Helicobacter pylori activities in vitro et al. Interestingly, previous studies have shown that pterodontic acid (1), a eudesmane-type sesquiterpene isolated from L. pterodonta (DC.), displays excellent selective antiviral activity to H1N1 subtype of influenza A virus. At the same time, our group also discovered that the antiviral activity of 1 was relatively close to that activity of post-marketed ribavirin. Therefore, we consider that the synthesis of pterodontic acid (1) derivatives and evaluation of their anti-influenza A virus (H1N1) activities is of potential clinical significance. In this manuscript, a series of pterodontic acid derivatives were prepared and demonstrated significantly improved anti-influenza A virus (H1N1) activities, providing more opportunities for the treatment of respiratory viral diseases.

• Authors: Yan-Jun Lin, Bang-Lian Huang, Shu-Ying Dai, Liu-Dong Song, Hao-Fei Yu, Xiao-Ling Yu, Rong-Ping Zhang
• Journal: Fitoterapia (Fitoterapia) Vol. 152 Pg. 104942 (Jul 2021) ISSN: 1873-6971 [Electronic] Netherlands
• PMID: 34029655 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2021 Elsevier B.V. All rights reserved.

Chemical References

• Antiviral Agents
• Sesquiterpenes
• pterodontic acid

Topics

• Animals
• Antiviral Agents (chemical synthesis, pharmacology)
• Asteraceae (chemistry)
• China
• Dogs
• Influenza A Virus, H1N1 Subtype (drug effects)
• Madin Darby Canine Kidney Cells
• Molecular Structure
• Sesquiterpenes (chemical synthesis, pharmacology)