Sortilin regulates keratinocyte proliferation and apoptosis through the PI3K-AKT signaling pathway.

Abstract

Sortilin is found to regulate proliferation and death of different cells, while its role in regulating keratinocyte proliferation and apoptosis is still unknown. In this study, we found that sortilin levels significantly increased in psoriasis patients, and sortilin suppression eliminated the proliferation of HaCaT cells induced by M5 cocktail solution and enhanced the levels of cleaved caspase 3 protein and the Bax/Bcl-2 ratio; however, levels of p-PI3K and p-AKT were decreased. In addition, sortilin silencing remitted the characteristic changes associated with psoriasis-like skin lesions. In summary, suppressed sortilin expression helped inhibit keratinocyte proliferation in HaCaT cells by inactivating PI3K/AKT signaling, which provides a new target for the therapy of psoriasis.

• Authors: Rui Zhang, Ye Hua Wang, Xin Shi, Jiang Ji, Fu Qin Zhan, Hong Leng
• Journal: Life sciences (Life Sci) Vol. 278 Pg. 119630 (Aug 01 2021) ISSN: 1879-0631 [Electronic] Netherlands
• PMID: 34004257 (Publication Type: Journal Article)
• Copyright: Copyright © 2021. Published by Elsevier Inc.

Chemical References

• Adaptor Proteins, Vesicular Transport
• Proto-Oncogene Proteins c-akt
• sortilin

Topics

• Adaptor Proteins, Vesicular Transport (pharmacology)
• Adolescent
• Adult
• Aged
• Animals
• Apoptosis
• Case-Control Studies
• Cell Proliferation
• Female
• Gene Expression Regulation
• Humans
• Keratinocytes (drug effects, metabolism, pathology)
• Male
• Mice
• Mice, Inbred BALB C
• Middle Aged
• Phosphatidylinositol 3-Kinases (genetics, metabolism)
• Proto-Oncogene Proteins c-akt (genetics, metabolism)
• Psoriasis (drug therapy, metabolism, pathology)
• Young Adult