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STAT6: A review of a signaling pathway implicated in various diseases with a special emphasis in its usefulness in pathology.

Abstract
Signal Transducer and Activator of Transcription 6 (STAT6), belonging to a family of seven similar members is primarily stimulated by interleukin(IL)-4 and IL-13, and acts as a T helper type 2 (Th2)-inducing factor. Thus, it is implicated in the pathophysiology of various allergic conditions, such as asthma, atopic dermatitis, eosinophilic esophagitis and food allergies, but also in tumor microenvironment regulation. Furthermore, certain forms of lymphomas, notably the Hodgkin lymphoma group, the primary mediastinal and primary central nervous system lymphoma, as well as some follicular and T cell lymphomas are associated with dysregulation of the STAT6 pathway. STAT6 immunohistochemical expression also serves as a surrogate marker in the diagnosis of solitary fibrous tumor, despite not directly responsible for the tumorigenic effect. These pathophysiological implications of the STAT6 pathway, its diagnostic or prognostic role in pathology, as well its immunohistochemical detection with different antibodies will be discussed in this review.
AuthorsGeorgia Karpathiou, Alexandra Papoudou-Bai, Elise Ferrand, Jean Marc Dumollard, Michel Peoc'h
JournalPathology, research and practice (Pathol Res Pract) Vol. 223 Pg. 153477 (Jul 2021) ISSN: 1618-0631 [Electronic] Germany
PMID33991851 (Publication Type: Journal Article, Review)
CopyrightCopyright © 2021 Elsevier GmbH. All rights reserved.
Chemical References
  • Biomarkers, Tumor
  • Inflammation Mediators
  • STAT6 Transcription Factor
  • STAT6 protein, human
Topics
  • Animals
  • Biomarkers, Tumor (metabolism)
  • Humans
  • Hypersensitivity (diagnosis, immunology, metabolism)
  • Immunohistochemistry
  • Inflammation (diagnosis, immunology, metabolism)
  • Inflammation Mediators (metabolism)
  • Lymphoma (immunology, metabolism, pathology)
  • Phosphorylation
  • Predictive Value of Tests
  • STAT6 Transcription Factor (metabolism)
  • Signal Transduction
  • Solitary Fibrous Tumors (immunology, metabolism, pathology)
  • Tumor Microenvironment (immunology)

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