Detrusor underactivity causes neurogenic voiding dysfunction in a rat bilateral accessory nerve-injury model.

Abstract

We aimed to investigate detrusor function in a previously developed rat neurogenic voiding dysfunction model that we have developed previously. We performed sham or bilateral accessory nerve injury (BACNI) surgeries on ten-week-old male Wistar/ST rats. One week after surgery, we evaluated detrusor contractility in the bladder using isometric tension and mRNA expression assays. Cholinergic contraction was attenuated in the injury model, whereas carbachol-evoked contraction was enhanced, and mRNA expression of the cholinergic receptor increased. These findings suggest that there was a reduction in neurotransmitter release causing detrusor underactivity.

• Authors: Kotomi Maeda, Yuji Hotta, Ryoya Kawata, Tomoya Kataoka, Kazunori Kimura
• Journal: Journal of pharmacological sciences (J Pharmacol Sci) Vol. 146 Issue 2 Pg. 116-119 (Jun 2021) ISSN: 1347-8648 [Electronic] Japan
• PMID: 33941322 (Publication Type: Journal Article)
• Copyright: Copyright © 2021 The Authors. Production and hosting by Elsevier B.V. All rights reserved.

Chemical References

• Neurotransmitter Agents
• RNA, Messenger
• Receptors, Cholinergic
• Carbachol

Topics

• Accessory Nerve Injuries (complications)
• Animals
• Carbachol (pharmacology)
• Disease Models, Animal
• Gene Expression
• Isometric Contraction (drug effects, genetics)
• Male
• Neurotransmitter Agents (metabolism)
• RNA, Messenger (genetics, metabolism)
• Rats, Wistar
• Receptors, Cholinergic (metabolism)
• Urinary Bladder (physiopathology)
• Urinary Bladder, Neurogenic
• Urinary Bladder, Underactive (complications, physiopathology)