Abstract | BACKGROUND: METHODS: This systematic review and meta-analysis includes randomized controlled trials (RCTs) targeting the effect of EN alone vs a combination of EN with PN in the acute phase of critical illness in adult patients. Assessed outcomes include mortality, intensive care unit (ICU) and hospital length of stay (LOS), ventilation days, infectious complications, physical recovery, and quality-of-life outcomes. RESULTS: Twelve RCTs with 5543 patients were included. Treatment with a combination of EN with PN led to increased delivery of macronutrients. No statistically significant effect of a combination of EN with PN vs EN alone on any of the parameters was observed: mortality (risk ratio = 1.0; 95% CI, 0.79-1.28; P = .99), hospital LOS (mean difference, -1.44; CI, -5.59 to 2.71; P = .50), ICU LOS, and ventilation days. Trends toward improved physical outcomes were observed in two of four trials. CONCLUSION: A combination of EN with PN improved nutrition intake in the acute phase of critical illness in adults and was not inferior regarding the patients' outcomes. Large, adequately designed trials in select patient groups are needed to answer the question of whether this nutrition strategy has a clinically relevant treatment effect.
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Authors | Aileen Hill, Daren K Heyland, Luis A Ortiz Reyes, Elena Laaf, Sebastian Wendt, Gunnar Elke, Christian Stoppe |
Journal | JPEN. Journal of parenteral and enteral nutrition
(JPEN J Parenter Enteral Nutr)
Vol. 46
Issue 2
Pg. 395-410
(02 2022)
ISSN: 1941-2444 [Electronic] United States |
PMID | 33899951
(Publication Type: Journal Article, Meta-Analysis, Systematic Review)
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Copyright | © 2021 The Authors. Journal of Parenteral and Enteral Nutrition published by Wiley Periodicals LLC on behalf of American Society for Parenteral and Enteral Nutrition. |
Topics |
- Adult
- Critical Illness
(therapy)
- Enteral Nutrition
- Humans
- Intensive Care Units
- Length of Stay
- Parenteral Nutrition
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