Roles and mechanisms of phospholipid transfer protein in the development of Alzheimer's disease.

Abstract

Phospholipid transfer protein (PLTP) is a complex glycosylated protein that mediates the transfer of phospholipids, unesterified cholesterol, diacylglycerides, specific apolipoproteins, and tocopherols between different classes of lipoproteins as well as between lipoproteins and cells. Many studies have associated PLTP with a variety of lipid metabolic diseases. However, recent studies have indicated that PLTP is highly expressed in the brain of vertebrate and may be related to many central nervous system diseases, such as Alzheimer's disease. Here, we review the data and report the role and mechanisms PLTP in Alzheimer's disease.

• Authors: Hao Wang, Mei-Hua Chen, Wei Chen, Ji-Guo Zhang, Shu-Cun Qin
• Journal: Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society (Psychogeriatrics) Vol. 21 Issue 4 Pg. 659-667 (Jul 2021) ISSN: 1479-8301 [Electronic] England
• PMID: 33851473 (Publication Type: Journal Article, Review)
• Copyright: © 2021 Japanese Psychogeriatric Society.

Chemical References

• Lipoproteins
• Phospholipid Transfer Proteins
• Cholesterol

Topics

• Alzheimer Disease
• Brain (metabolism)
• Cholesterol
• Humans
• Lipoproteins
• Phospholipid Transfer Proteins (metabolism)