Abstract | INTRODUCTION: MATERIALS AND METHODS: We retrospectively analyzed the data of 125 patients with non-muscle invasive bladder cancer who received BCG immunotherapy. Of these, 61 progressed to muscle-invasive disease or had high-grade recurrence. These patients were compared with the group who did not progress (n = 64). Clinical data including stage, grade, age, gender, smoking status and observational time was collected. Besides, information on blood count analysis was obtained from ambulatory digital charts. On this basis neutrophil-to-lymphocyte ratio (NLR), platelet-to lymphocyte ratio (PLR) and lymphocyte-to-monocyte ratio (LMR) was counted and compared between groups. RESULTS: NLR, PLR and LMR were shown to be independent prognostic markers of progression in multivariable analysis. The model with stage, grade, age, gender, smoking status and LMR had the highest prognostic values of all models (area under curve [AUC] = 0.756). The cut-off point according to ROC curves for LMR was 3.25. Adding LMR to the baseline model including clinical variables significantly increased area under curve by 0.08 (p = 0.001). NLR and PLR did not increase areas under curve significantly to baseline model. CONCLUSIONS:
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Authors | Mateusz Adamkiewicz, Piotr Bryniarski, Maksymilian Kowalik, Bartłomiej Burzyński, Paweł Rajwa, Andrzej Paradysz |
Journal | Frontiers in oncology
(Front Oncol)
Vol. 11
Pg. 655000
( 2021)
ISSN: 2234-943X [Print] Switzerland |
PMID | 33842371
(Publication Type: Journal Article)
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Copyright | Copyright © 2021 Adamkiewicz, Bryniarski, Kowalik, Burzyński, Rajwa and Paradysz. |