By 9 February 2021, the Coronavirus has killed 2,336,650 people worldwide and it has been predicted that this number continues to increase in year 2021. The study aimed to identify therapeutic approaches and drugs that can potentially be used as interventions in Coronavirus 2019 (COVID-19) management. A systematic scoping review was conducted. Articles reporting clinical evidence of therapeutic management of
COVID-19 were selected from three different research databases (Google Scholar, PubMed, and Science Direct). From the database search, 31 articles were selected based on the study inclusion and exclusion criteria. This review paper showed that
remdesivir and
ivermectin significantly reduced viral
ribonucleic acid (
RNA) activity. On the other hand, convalescent plasma (CP) significantly improved
COVID-19 clinical symptoms. Additionally, the use of
corticosteroid increased survival rates in
COVID-19 patients with
acute respiratory distress syndrome (ARDS). Findings also indicated that both
hydroxychloroquine and
favipiravir were effective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However,
lopinavir-
ritonavir combination was not effective against
COVID-19. Finally,
ribavirin,
galidesivir, and
sofosbuvir showed potential therapeutic benefit in treating
COVID-19, but there is a lack of clinical evidence on their effectiveness against SARS-CoV-2.
Remdesivir,
ivermectin,
favipiravir,
hydroxychloroquine,
dexamethasone,
methylprednisolone, and CP are the therapeutic agents that can potentially be used in
COVID-19 management.