Abstract |
Nearly 2 decades since its discovery as one of the genes responsible for the Wolf-Hirschhorn Syndrome (WHS), the primary function of the leucine-zipper EF-hand containing transmembrane 1 (LETM1) protein in the inner mitochondrial membrane (IMM) or the mechanism by which it regulates mitochondrial Ca2+ handling is unresolved. Meanwhile, LETM1 has been associated with the regulation of fundamental cellular processes, such as development, cellular respiration and metabolism, and apoptosis. This mini-review summarizes the diversity of cellular functions impacted by LETM1 and highlights the multiple roles of LETM1 in health and disease.
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Authors | Gayathri K Natarajan, Jyotsna Mishra, Amadou K S Camara, Wai-Meng Kwok |
Journal | Frontiers in physiology
(Front Physiol)
Vol. 12
Pg. 637852
( 2021)
ISSN: 1664-042X [Print] Switzerland |
PMID | 33815143
(Publication Type: Journal Article, Review)
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Copyright | Copyright © 2021 Natarajan, Mishra, Camara and Kwok. |