Abstract | AIM: To determine whether differences in joint and tendon stiffness as measured by ultrasound shear wave elastography are present in breast cancer patients with aromatase inhibitor-associated arthralgias compared to age-comparable healthy control women. METHODS: Postmenopausal women with stage I-III breast cancer who were taking adjuvant aromatase inhibitors and complained of joint pain were enrolled (n = 6). Postmenopausal women with no history of breast cancer, hormone treatment, or joint pain served as controls (n = 7). All subjects had bilateral hands and wrists evaluated by gray-scale and power Doppler ultrasound, and shear wave elastography ultrasound. RESULTS: Patients with AI-associated arthralgias had significantly stiffer tendons than controls in the 1st extensor compartment (long axis; p = 0.001), 4th extensor compartment (long axis; p = 0.014), 3rd metacarpophalangeal joint (p = 0.002), the pooled values of the extensor compartments, both long (p = 0.044) and short axes (p = 0.035), and the pooled values for the metacarpophalangeal joints (p = 0.002). On ultrasound, the patients (but not controls) presented with hyperemia and increased tenosynovial fluid in the flexor and extensor tendon sheaths, and the median nerves were symptomatic and bifid; however, these differences were not statistically significant. CONCLUSIONS:
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Authors | Jessica A Martinez, Mihra S Taljanovic, Russell S Witte, Andres A Nuncio Zuniga, Betsy C Wertheim, C Kent Kwoh, Brian A Goldstein, Denise J Roe, Pavani Chalasani |
Journal | Journal of ultrasonography
(J Ultrason)
Vol. 21
Issue 84
Pg. 1-6
( 2021)
ISSN: 2084-8404 [Print] Poland |
PMID | 33791110
(Publication Type: Journal Article)
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Copyright | © Polish Ultrasound Society. |