Use of topical anti-inflammatory and antineoplastic agents in the treatment of young-aged actinic cheilitis: A systematic review.

Abstract

INTRODUCTION:

Several treatments have been used to reduce inflammation and to reverse epithelial alterations in actinic cheilitis (AC).

AIM:

A systematic review was conducted to analyze the potential of topical treatments for remission and clinical improvement of AC as well as patient acceptability.

METHODS:

A systematic review of clinical trials was conducted following the PICO strategy to answer the following question: Are topical anti-inflammatory and antineoplastic agents effective in the treatment of actinic cheilitis? The quality of the studies was assessed by ROB-2, and the certainty of evidence was rated by GRADE guidelines.

RESULTS:

Eight clinical trials were selected, including four that investigated the use of anti-inflammatory drugs and four use of antineoplastic agents. The use of 3% diclofenac sodium was associated with partial remission of AC, while 5% imiquimod and ingenol mebutate promoted complete remission. Furthermore, 5% fluorouracil was the drug most associated with complications during treatment. Diclofenac sodium (3%) and fludroxycortide showed the best acceptance by the patients, especially in terms of symptom relief and comfort provided.

CONCLUSION:

The anti-inflammatory and antineoplastic agents analyzed largely provided good clinical outcomes, with evidence of remission of AC lesions, development of few local adverse reactions during treatment, and good patient adherence.

• Authors: Cristianne Kalinne Santos Medeiros, Glória Maria de França, Jabes Gennedyr da Cruz Lima, Juliana Campos Pinheiro, Dennys Ramon de Melo Fernandes Almeida, Pedro Paulo de Andrade Santos
• Journal: Journal of cosmetic dermatology (J Cosmet Dermatol) Vol. 21 Issue 2 Pg. 473-481 (Feb 2022) ISSN: 1473-2165 [Electronic] England
• PMID: 33786961 (Publication Type: Journal Article, Systematic Review)
• Copyright: © 2021 Wiley Periodicals LLC.

Chemical References

• Anti-Inflammatory Agents
• Antineoplastic Agents

Topics

• Aged
• Anti-Inflammatory Agents (adverse effects)
• Antineoplastic Agents (adverse effects)
• Cheilitis (drug therapy)
• Humans
• Treatment Outcome