Abstract | OBJECTIVE: METHODS: A total number of 60 women with GDM and 70 women without GDM (non-GDM) were included in the study. Placental NGF and BDNF levels were measured using commercially available ELISA kits. RESULTS: Placental NGF levels were lower (p < .05) in women with GDM compared to non-GDM women. Maternal body mass index (BMI), mode of delivery, and the gender of the baby influenced the placental NGF levels. Placental BDNF levels were similar in GDM and non-GDM women. There was an influence of baby gender on the placental BDNF levels while maternal BMI and mode of delivery did not show any effect. In regression models adjusted for maternal age at delivery, gestational age, maternal BMI, mode of delivery, and baby gender, the placental NGF levels in the GDM group were lower (-0.144 pg/ml [95% CI -0.273, 22120.016] p = .028) as compared to the non-GDM group. However, there was no difference in the BDNF levels between the groups. CONCLUSION: This study for the first time demonstrates differential effects on neurotrophic factors such as BDNF and NGF in the placenta in pregnancies complicated by GDM. Alterations in the levels of placental neurotrophins in GDM deliveries may affect placental development and fetal brain growth. This has implications for increased risk for neurodevelopmental pathologies in later life.
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Authors | Anjali Jadhav, Amrita Khaire, Shridevi Gundu, Nisha Wadhwani, Nomita Chandhiok, Sanjay Gupte, Sadhana Joshi |
Journal | International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
(Int J Dev Neurosci)
Vol. 81
Issue 4
Pg. 352-363
(Jun 2021)
ISSN: 1873-474X [Electronic] United States |
PMID | 33783008
(Publication Type: Journal Article)
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Copyright | © 2021 International Society for Developmental Neuroscience. |
Chemical References |
- Brain-Derived Neurotrophic Factor
- Nerve Growth Factor
|
Topics |
- Adult
- Body Mass Index
- Brain-Derived Neurotrophic Factor
(metabolism)
- Diabetes, Gestational
(metabolism)
- Female
- Humans
- Nerve Growth Factor
(metabolism)
- Placenta
(metabolism)
- Pregnancy
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