Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: AIM OF THE STUDY: METHODS AND MATERIALS: We used estrogen ( estradiol) to induce endometrial hyperplasia in mice. C57BL/6 mice were treated with estradiol subcutaneously for 21 days, and GFC (75 mg/kg and 150 mg/kg) was given intragastric administration from the first day of the modeling. H&E staining is used to evaluate endometrial tissue structure change. Malondialdehyde was measured to explore lipid peroxidation. Western blot, immunohistochemistry and immunofluorescence were performed to observe the expressions of GPX4, p62, Keap1 and NRF2. RESULTS: CONCLUSIONS:
|
Authors | Minyi Zhang, Tao Zhang, Chenglin Song, Jiao Qu, Yanpin Gu, Songjun Liu, Haibo Li, Wei Xiao, Lingdong Kong, Yang Sun, Wen Lv |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 274
Pg. 114064
(Jun 28 2021)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 33771639
(Publication Type: Journal Article)
|
Copyright | Copyright © 2021 Elsevier B.V. All rights reserved. |
Chemical References |
- Capsules
- Drugs, Chinese Herbal
- Estrogens
- Keap1 protein, mouse
- Kelch-Like ECH-Associated Protein 1
- NF-E2-Related Factor 2
- Nfe2l2 protein, mouse
- RNA-Binding Proteins
- guizhi-fuling
- Estradiol
- Malondialdehyde
- Phospholipid Hydroperoxide Glutathione Peroxidase
- glutathione peroxidase 4, mouse
|
Topics |
- Animals
- Capsules
- Drugs, Chinese Herbal
(pharmacology, therapeutic use)
- Endometrial Hyperplasia
(chemically induced, drug therapy, metabolism, pathology)
- Endometrium
(drug effects, metabolism, pathology)
- Estradiol
- Estrogens
- Female
- Ferroptosis
(drug effects)
- Kelch-Like ECH-Associated Protein 1
(metabolism)
- Malondialdehyde
(metabolism)
- Medicine, Chinese Traditional
- Mice, Inbred C57BL
- NF-E2-Related Factor 2
(metabolism)
- Phospholipid Hydroperoxide Glutathione Peroxidase
(metabolism)
- RNA-Binding Proteins
(metabolism)
|