Evaluation of perilipin 2 and melanocortin 5 receptor serum levels with sebogenesis in acne vulgaris patients.

Abstract

INTRODUCTION:

Acne vulgaris is a multifactorial disease. One of the main factors that plays a role in acne pathogenesis is an increase in sebum secretion. For sebum secretion, sebocyte differentiation followed by sebogenesis is essential. Sebocyte differentiation and proliferation, and sebum synthesis are controlled by complex pathways. Studies have shown that perilipin 2 and melanocortin 5 receptors play a role in sebogenesis. This study sought to determine whether levels of perilipin 2 and melanocortin 5 receptors have an impact on the development of acne vulgaris.

METHODS:

A total of 65 patients diagnosed with acne and 43 healthy control subjects were included in the study. Perilipin 2 and melanocortin 5 receptor levels were analyzed using the enzyme-linked immunosorbent assay (ELISA) technique.

RESULTS:

No significant differences were observed between the acne group and the control group in serum perilipin 2 (p = 0.594) and melanocortin 5 receptor (p = 0.213) levels. In the moderate acne group, perilipin 2 and melanocortin 5 receptor levels were significantly higher than in the mild acne group (p = 0.0014, p = 0.003). The levels in the severe acne group were not higher compared to the moderate and mild acne groups.

CONCLUSION:

This study failed to detect any association between acne pathogenesis and perilipin 2 and melanocortin 5 receptor serum levels. However, these proteins may have an influence on acne severity.

• Authors: Özge Mine Örenay, Evren Sarıfakıoğlu, Ayla Gülekon
• Journal: Acta dermatovenerologica Alpina, Pannonica, et Adriatica (Acta Dermatovenerol Alp Pannonica Adriat) Vol. 30 Issue 1 Pg. 7-9 (Mar 2021) ISSN: 1581-2979 [Electronic] Slovenia
• PMID: 33765750 (Publication Type: Journal Article)

Chemical References

• PLIN2 protein, human
• Perilipin-2
• Receptors, Melanocortin
• melanocortin 5 receptor

Topics

• Acne Vulgaris
• Humans
• Perilipin-2
• Receptors, Melanocortin (metabolism)
• Sebaceous Glands