Abstract | BACKGROUND: METHODS: This retrospective study examined NMOSD patients who had undergone either LPE or TPE treatment between January 2015 and January 2018. The patients were monitored for improvements in disabilities, incidences of adverse reactions, and safety of the procedure over a one-year follow-up period. The primary outcome measures included changes in the visual outcome scale (VOS) score, the expanded disability status scale (EDSS), and the annualized relapse rate (ARR). RESULTS: Neurological function and objective response rates were significantly improved in 76.5% of patients treated with LPE and 83.3% of patients treated with TPE. There were no significant differences in the two treatment groups (P=0.392). Similarly, there were no differences in the reduction in the relative relapse rate between the two groups (P=0.494). Adverse reactions, mostly of mild or moderate intensity, were recorded in 9.3% of procedures in 38% of patients. The most commonly observed adverse events (AEs) were similar between the two treatment cohorts. CONCLUSIONS: Patients treated with LPE showed improved neurological function comparable to that reported with TPE treatment. No superiority was shown for either of the apheresis techniques.
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Authors | Leiying Zhang, Yuan Zhuang, Xiaomin Liu, Quangang Xu, Lingling Zhou, Liyang Zou, Ying Jiang, Jing Tian, Huan Yao, Hongxu Chi, Xuede Qiu, Tianxin Yang, Deqing Wang, Yang Yu |
Journal | Annals of palliative medicine
(Ann Palliat Med)
Vol. 10
Issue 3
Pg. 3105-3114
(Mar 2021)
ISSN: 2224-5839 [Electronic] China |
PMID | 33752428
(Publication Type: Journal Article)
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Topics |
- Blood Component Removal
- Humans
- Neuromyelitis Optica
(therapy)
- Optic Neuritis
(therapy)
- Retrospective Studies
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