Abstract | BACKGROUND: METHODS: We retrospectively reviewed the medical records of 149 patients with LS-SCLC who received first-line treatment between January 2009 and December 2016. RESULTS: In the univariate analysis, the patients with ILAs showed a higher incidence rate of radiation pneumonitis compared with those without ILAs (64% vs. 10%, P < 0.001). Multivariate analysis confirmed that ILAs were significantly associated with the incidence of radiation pneumonitis. In the univariate analysis, patients with ILAs showed poorer overall survival than those without ILAs (median, 18.9 vs. 67.9 months, P = 0.0338). Multivariate analysis showed that ILAs were a significant independent negative prognostic factor. However, the 2-year and 5-year survival rates for the patients with ILAs treated with chemoradiotherapy were 36% and 26%, respectively, and 8% and 0%, respectively, for those treated with chemotherapy alone. CONCLUSIONS:
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Authors | Haruki Kobayashi, Kazushige Wakuda, Tateaki Naito, Nobuaki Mamesaya, Shota Omori, Akira Ono, Hirotsugu Kenmotsu, Haruyasu Murakami, Masahiro Endo, Hideyuki Harada, Yasuhiro Gon, Toshiaki Takahashi |
Journal | Radiation oncology (London, England)
(Radiat Oncol)
Vol. 16
Issue 1
Pg. 52
(Mar 17 2021)
ISSN: 1748-717X [Electronic] England |
PMID | 33731123
(Publication Type: Journal Article)
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Topics |
- Adult
- Aged
- Chemoradiotherapy
(adverse effects, mortality)
- Female
- Humans
- Incidence
- Lung Diseases, Interstitial
(complications, mortality, pathology, therapy)
- Lung Neoplasms
(complications, mortality, pathology, therapy)
- Male
- Middle Aged
- Prognosis
- Radiation Pneumonitis
(epidemiology, etiology)
- Retrospective Studies
- Small Cell Lung Carcinoma
(complications, mortality, pathology, therapy)
- Survival Rate
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