Abstract | BACKGROUND: AIMS: SUMMARY OF REVIEW: Studies reporting aspirin use and the occurrence of subarachnoid hemorrhage were included and grouped based on population (general population vs. aneurysm population). Odds ratios, hazard ratios, and confidence intervals were combined in random-effects models. Eleven studies were included. Overall, there was an association between aspirin and subarachnoid hemorrhage (OR 0.68 [0.48, 0.96]). However, populations were diverse and heterogeneity between studies high (p < 0.00001), questioning the validity of combining these studies and justifying analysis by population. In the general population, there was no difference in aspirin use between individuals with and without subarachnoid hemorrhage (OR 1.15 [0.96, 1.38]). In patients with intracranial aneurysms, aspirin use was greater in patients without subarachnoid hemorrhage (OR 0.37 [0.24, 0.58]), although these studies were at higher risk of bias. CONCLUSIONS:
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Authors | Frederick Ewbank, Jacqueline Birks, Diederik Bulters |
Journal | International journal of stroke : official journal of the International Stroke Society
(Int J Stroke)
Vol. 17
Issue 3
Pg. 341-353
(Mar 2022)
ISSN: 1747-4949 [Electronic] United States |
PMID | 33705214
(Publication Type: Journal Article, Meta-Analysis)
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Chemical References |
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Topics |
- Aneurysm, Ruptured
- Aspirin
(adverse effects)
- Humans
- Intracranial Aneurysm
(complications, drug therapy, epidemiology)
- Prospective Studies
- Stroke
- Subarachnoid Hemorrhage
(complications, epidemiology)
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