Abstract |
Two currently used methods of determining fetal pulmonary maturity were verified on the basis of 148 amniotic fluid samples: one dimensional sequential thin-layer chromatographic determination of the lecithin: sphingomyelin ratio and of phosphatidyl glycerol, and an immunologic slide detection of phosphatidyl glycerol (Amniostat-FLM). With both methods, which have the advantage that they can be performed quickly and can sometimes even be used at the bedside (Amniostat-FLM), a respiratory distress syndrome in the newborn can be ruled out with a high degree of confidence if the threshold values are exceeded (L/S greater than 2; phosphatidyl glycerol present). As with all historical methods, the positive correctness of these two modern methods (no RDS if the child is born within 72 hours despite a negative phosphatidyl glycerol test in the amniotic fluid) is low. Clearly, apart from the quantitative existence of certain surfactant phospholipids ( lecithin, phosphatidyl glycerol), there are other perinatal events or measures which determine the extent and severity of RDS in the immature newborn.
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Authors | U Lorenz, H K Weitzel, V Ragosch, H Gips |
Journal | Zeitschrift fur Geburtshilfe und Perinatologie
(Z Geburtshilfe Perinatol)
1988 Jan-Feb
Vol. 192
Issue 1
Pg. 1-6
ISSN: 0300-967X [Print] Germany |
Vernacular Title | Aktuelle Methoden zur antepartalen Lungenreifebestimmung des Kindes aus dem Fruchtwasser. |
PMID | 3369221
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Phosphatidylglycerols
- Phospholipids
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Topics |
- Agglutination Tests
- Amniocentesis
- Amniotic Fluid
(metabolism)
- Chromatography, Thin Layer
- Female
- Fetal Growth Retardation
(diagnosis)
- Fetal Organ Maturity
- Humans
- Infant, Newborn
- Lung
(embryology)
- Phosphatidylglycerols
(metabolism)
- Phospholipids
(metabolism)
- Pregnancy
- Prenatal Diagnosis
- Respiratory Distress Syndrome, Newborn
(diagnosis)
- Risk Factors
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