Abstract | OBJECTIVE: METHODS: A systematic search of the literature was performed, and all the eligible randomized controlled trials were included in the meta-analysis and trial sequential analysis. RESULTS: A total of 454 articles were identified using the search criteria. Six articles were selected for systematic review and the 4 randomized controlled trials were included in the meta-analysis. The pooled odds ratio for symptomatic vasospasm, new-onset infarct, and angiographic vasospasm was 0.35 (95% confidence interval [CI], 0.21-0.59; P < 0.0001), 0.38 (95% CI, 0.21-0.66; P = 0.0007) and 0.49 (95% CI, 0.31-0.80; P = 0.004), respectively. The pooled risk ratio for unfavorable outcome was 0.52 (95% CI, 0.37-0.74; P = 0.0003). CONCLUSIONS:
Cilostazol decreases the prevalence of symptomatic vasospasm, new-onset infarct, and angiographic vasospasm when administered after aSAH. Trial sequential analysis increased the precision of our results because the defined thresholds of effect were met by the available studies. However, further studies involving patients from other geographic areas are required to confirm the generalization of the results.
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Authors | Sandeep Bohara, Kanwaljeet Garg, Preet Mohinder Singh Rajpal, Manish Kasliwal |
Journal | World neurosurgery
(World Neurosurg)
Vol. 150
Pg. 161-170
(06 2021)
ISSN: 1878-8769 [Electronic] United States |
PMID | 33631387
(Publication Type: Journal Article, Meta-Analysis, Systematic Review)
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Copyright | Copyright © 2021 Elsevier Inc. All rights reserved. |
Chemical References |
- Phosphodiesterase 3 Inhibitors
- Cilostazol
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Topics |
- Cilostazol
(therapeutic use)
- Humans
- Phosphodiesterase 3 Inhibitors
(therapeutic use)
- Randomized Controlled Trials as Topic
- Subarachnoid Hemorrhage
(complications)
- Treatment Outcome
- Vasospasm, Intracranial
(etiology, prevention & control)
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