Ipsilateral late stroke after revascularization surgery for patients with Moyamoya disease.

Abstract

BACKGROUND:

Ipsilateral late stroke events occurring after cerebral revascularization for Moyamoya disease (MMD) and their risk factors have not been fully investigated.

METHODS:

We retrospectively analyzed 123 patients with MMD who underwent 212 revascularizations. We investigated preoperative demographic data, surgical procedures, and ipsilateral stroke events occurring more than 1 month after surgery. The effect of revascularization and the residual Moyamoya vessel (MMV) score were examined using magnetic resonance angiography (MRA). Then, predictive factors for postoperative late stroke occurrence were evaluated by logistic regression.

RESULTS:

The mean age was 26 ± 18.4 years (range 1 to 66 years). Ipsilateral late stroke events were present in 11 of 123 (9%) patients. Stroke occurred in 11 out of 212 surgeries (5.2%) on a hemispheric basis. During the 1300.1 hemisphere-years of follow-up more than 1 month after surgery, the annual stroke rate was 0.84%. The postoperative MRA time-of-flight image showed a mean revascularization score of 1.82 ± 0.6 and a mean residual MMV score of 1.91 ± 0.83. Postoperative strokes occurring within 1 month after cerebral revascularization (36.4%, p = 0.0026) and lower revascularization scores (1.82 ± 0.6 vs 2.51 ± 0.59, p = 0.0006) were significant factors related to the presence of ipsilateral late stroke. Logistic regression showed that stroke events within 1 month after revascularization (odds ratio [OR], 9.79; 95% confidence interval [CI], 0.02-0.57; p = 0.0103), low revascularization score (OR, 0.15; 95% CI, 0.001-0.37; p = 0.0069), and high residual MMV score (OR, 16.2; 95% CI, 1.88-187.4; p = 0.0107) were risk factors for ipsilateral stroke more than 1 month after revascularization.

CONCLUSIONS:

MMD patients who have a stroke within 1 month after cerebral revascularization are at high risk for late strokes. Less effective revascularization or remarkable residual MMV are risk factors for late stroke events. Additional revascularization may be considered for patients in such situations.

CLINICAL TRIAL REGISTRATION:

This study was approved by the Bioethics Review Committee of Nagoya University Hospital for the treatment and prognosis of Moyamoya disease (2016-0327).

• Authors: Yoshio Araki, Kinya Yokoyama, Kenji Uda, Fumiaki Kanamori, Takashi Mamiya, Masahiro Nishihori, Masaki Sumitomo, Sho Okamoto, Takashi Izumi
• Journal: Acta neurochirurgica (Acta Neurochir (Wien)) Vol. 163 Issue 5 Pg. 1493-1502 (05 2021) ISSN: 0942-0940 [Electronic] Austria
• PMID: 33624115 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Adolescent
• Adult
• Aged
• Cerebral Revascularization (adverse effects)
• Child
• Child, Preschool
• Humans
• Infant
• Male
• Middle Aged
• Moyamoya Disease (surgery)
• Postoperative Complications (epidemiology, etiology)
• Stroke (epidemiology, etiology)