Abstract | PURPOSE: MATERIALS AND METHODS: The microRNA expression profiles of eight saliva samples (four collected from patients with peri-implantitis, four collected from patients who have successful implants) were investigated, and the deregulation of select microRNAs was further confirmed using quantitative polymerase chain reaction. RESULTS: The expressions of 179 microRNAs were found as deregulated in the saliva of peri-implantitis patients in comparison to controls. Then, downregulation of miR-4484 was confirmed in the saliva of peri-implantitis patients in a larger validation cohort. Also, 40% of non- peri-implantitis patients and 78% of peri-implantitis patients had significantly decreased miR-4484 expression in saliva samples collected after 4 to 6 months subsequent to implant placement compared with samples collected before implant placement. CONCLUSION: Considering these findings, microRNA content of saliva might be proposed as a plausible source for the early diagnosis of peri-implantitis, where miR-4484 might serve as an encouraging early diagnostic biomarker.
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Authors | Gelengul Urvasizoglu, Ahsen Kilic, Neslisah Barlak, Mustafa Gundogdu, Omer Faruk Karatas |
Journal | The International journal of oral & maxillofacial implants
(Int J Oral Maxillofac Implants)
2021 Jan-Feb
Vol. 36
Issue 1
Pg. 115-121
ISSN: 1942-4434 [Electronic] United States |
PMID | 33600531
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Dental Implants
- MicroRNAs
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Topics |
- Biomarkers
- Dental Implants
(adverse effects)
- Early Diagnosis
- Humans
- MicroRNAs
(genetics)
- Peri-Implantitis
(diagnosis)
- Saliva
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