Efficient Iron and ROS Nanoscavengers for Brain Protection after Intracerebral Hemorrhage.

Abstract

Intracerebral hemorrhage (ICH) will be accompanied by the overload of iron and reactive oxygen species (ROS) following hematoma clearance. Although deferoxamine (DFO) has been widely utilized as a clinical first-line siderophore to remove the iron overload, the ROS-inducing damage still greatly limits the therapeutic effect of DFO. To address this issue, we designed and fabricated a series of dual-functional macromolecular nanoscavengers featuring high-density DFO units and catechol moieties. Note that the former units could effectively remove the iron overload, while the latter ones could efficiently deplete the ROS. The resulting nanoscavengers efficiently down-regulate the iron and ROS levels as well as significantly reduce the cell death in both iron-overloaded RAW 264.7 cells and the ICH mice model. This work suggests a novel clue for the ICH-ameliorated iron-depleting interventional therapeutic regimen.

• Authors: Fang Zhu, Liu Zi, Peng Yang, Yang Wei, Rui Zhong, Yan Wang, Chao You, Yiwen Li, Meng Tian, Zhipeng Gu
• Journal: ACS applied materials & interfaces (ACS Appl Mater Interfaces) Vol. 13 Issue 8 Pg. 9729-9738 (Mar 03 2021) ISSN: 1944-8252 [Electronic] United States
• PMID: 33599495 (Publication Type: Journal Article)

Chemical References

• Antioxidants
• Catechols
• Neuroprotective Agents
• Polymers
• Reactive Oxygen Species
• Siderophores
• Iron
• Collagenases
• Deferoxamine

Topics

• Animals
• Antioxidants (chemical synthesis, therapeutic use)
• Brain (drug effects, metabolism, physiopathology)
• Catechols (chemical synthesis, therapeutic use)
• Cerebral Hemorrhage (chemically induced, complications, drug therapy, physiopathology)
• Collagenases
• Deferoxamine (analogs & derivatives, therapeutic use)
• Iron (metabolism)
• Iron Overload (drug therapy, etiology, physiopathology)
• Male
• Mice
• Mice, Inbred BALB C
• Neuroprotective Agents (chemical synthesis, therapeutic use)
• Polymers (chemical synthesis, therapeutic use)
• RAW 264.7 Cells
• Reactive Oxygen Species (metabolism)
• Siderophores (chemical synthesis, therapeutic use)