Walking Initiated 20 Minutes before the Time of Individual Postprandial Glucose Peak Reduces the Glucose Response in Young Men with Overweight or Obesity: A Randomized Crossover Study.

Abstract

BACKGROUND:

Although a single bout of postmeal exercise can lower postprandial glucose (PPG), its optimal timing remains unclear.

OBJECTIVE:

This study aimed to investigate the effect of exercise timing using an individualized approach on PPG in overweight or obese young men.

METHODS:

Twenty men [age: 23.0 ± 4.3 y; BMI (kg/m2): 27.4 ± 2.8] each completed three 240-min trials in a randomized order separated by 6-14 d: 1) sitting (SIT), 2) walking initiated at each participant's PPG-peak time (PPGP) (iP), and 3) walking initiated 20 min before the PPGP (20iP). For each participant, PPGP was predetermined using continuous glucose monitoring. Walking was performed at 50% maximal oxygen consumption for 30 min. Venous blood was collected at 15- and 30-min intervals for 0-120 min and 120-240 min, respectively. The primary outcome was plasma PPG. Generalized estimating equations were used for comparison between trials.

RESULTS:

Compared with SIT, the 4-h incremental AUCs (iAUCs) for plasma PPG (-0.6 mmol · L-1 · h; P = 0.047) and insulin (-28.7%, P < 0.001) were reduced in 20iP only, and C-peptide concentrations were lower after iP (-14.9%, P = 0.001) and 20iP (-28.7%, P < 0.001). Plasma insulin (-11.1%, P = 0.006) and C-peptide (-8.3%, P = 0.012) were lower due to the 20iP compared with iP treatment. Finally, PPG reductions due to iP and 20iP occurred only in men with a BMI > 27.5 kg/m2 (iP, -11.2%; 20iP, -14.7%; P = 0.047) and higher glucose iAUC values during SIT (iP, -25.5%; 20iP, -25.7%; P < 0.001).

CONCLUSIONS:

Walking initiated 20 min before PPGP lowered PPG and plasma insulin and C-peptide concentrations in young men with overweight or obesity, in particular in those with high BMI or glucose iAUC values during SIT; it also lowered plasma insulin and C-peptide concentrations more effectively than did exercise initiated at PPGP. This trial was registered at the Chinese Clinical Trial Registry (http://www.chictr.org.cn/index.aspx) as ChiCTR1900023175.

• Authors: Xiaoyuan Zhang, Waris Wongpipit, Fenghua Sun, Sinead Sheridan, Wendy Y J Huang, Cindy H P Sit, Stephen H S Wong
• Journal: The Journal of nutrition (J Nutr) Vol. 151 Issue 4 Pg. 866-875 (04 08 2021) ISSN: 1541-6100 [Electronic] United States
• PMID: 33561220 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: © The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.

Chemical References

• Blood Glucose
• C-Peptide
• Insulin

Topics

• Adolescent
• Adult
• Blood Glucose (isolation & purification)
• C-Peptide (blood)
• Cross-Over Studies
• Exercise (physiology)
• Heart Disease Risk Factors
• Humans
• Insulin (blood)
• Male
• Obesity (blood, physiopathology)
• Overweight (blood, physiopathology)
• Postprandial Period (physiology)
• Time Factors
• Walking (physiology)
• Young Adult