Short communication: Algicide activity of antimicrobial peptides compounds against Prototheca bovis.

Abstract

This study evaluated the in vitro activity of antimicrobial peptides pexiganan (MSI-78), h-Lf1-11, LL-37, cecropin B, magainin-2, and fengycin B against the veterinary mastitis agent Prototheca bovis. The results showed that pexiganan, h-Lf1-11, LL-37, and cecropin B were able to inhibit the growth and had effect on algicide P. bovis isolates (n = 32). The minimum inhibitory concentration ranged from 5 to 10 µg/mL for pexiganan, and algicide effect was detected from 5 to 20 µg/mL. The minimum inhibitory concentration ranged from 10 to 80 µg/mL for h-Lf1-11, 20 to 80 µg/mL for LL-37, and 40 to 160 µg/mL for cecropin B. These findings present a promising and novel alternative for P. bovis treatment and growth control.

• Authors: V R Sperotto, L B Denardi, C Weiblen, F P K de Jesus, M R Dorneles, L B Ianiski, J M Santurio
• Journal: Journal of dairy science (J Dairy Sci) Vol. 104 Issue 3 Pg. 3554-3558 (Mar 2021) ISSN: 1525-3198 [Electronic] United States
• PMID: 33455795 (Publication Type: Journal Article)
• Copyright: Copyright © 2021 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Chemical References

• Anti-Bacterial Agents
• Herbicides
• Pore Forming Cytotoxic Proteins

Topics

• Animals
• Anti-Bacterial Agents (pharmacology)
• Female
• Herbicides
• Microbial Sensitivity Tests
• Pore Forming Cytotoxic Proteins
• Prototheca