Comparison of nomifensine and placebo.

Abstract

1. Methodological reasons are discussed which make placebo-controlled trials on antidepressant drugs necessary. 2. The ethical problem of treating a sick patient with an inactive compound are shown to have an impact on the methodology of such trials. 3. Three double-blind placebo-controlled trials with nomifensine are reviewed; one in neurotic depression, one in psychotic depression and one in geriatric patients showing depressive symptoms. 4. In all three trials the effect of nomifensine has been shown to be superior to that of placebo.

• Authors: K Taeuber
• Journal: British journal of clinical pharmacology (Br J Clin Pharmacol) Vol. 4Suppl 2 Pg. 209S-213S ( 1977) ISSN: 0306-5251 [Print] England
• PMID: 334225 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)

Chemical References

• Isoquinolines
• Placebos
• Nomifensine

Topics

• Adjustment Disorders (drug therapy)
• Affective Disorders, Psychotic (drug therapy)
• Aged
• Clinical Trials as Topic
• Depression (drug therapy)
• Double-Blind Method
• Drug Evaluation
• Humans
• Isoquinolines (therapeutic use)
• Middle Aged
• Nomifensine (therapeutic use)
• Placebos (therapeutic use)