Abstract | PURPOSE: METHODS: We searched PubMed, Embase, and Cochrane Library for relevant studies before January 2020. We performed a random-effects NMA using STATA version 15.1 to assess mean difference and odds ratios with 95% confidence intervals. RESULTS: We identified twelve retrospective trails and five randomized controlled trials (RCTs), comprising 1 492 patients of IMH on stage II-IV for ILM peeling. The results of IMH closure rate show that the effect of ILM peeling without dye was better than 0.25% ICG, the effects of ILM peeling with 0.5% ICG or TA were better than without dye, and the effects of ILM peeling with 0.05% BBG, 0.15% TB, 0.5% ICG or 0.05% ICG were better than 0.25% ICG. Ranking probability analysis shows that the rates of IMH closure after ILM peeling with 0.15% TB or 0.05% BBG were better than nine other concentrations of chromovitrectomy dyes. CONCLUSION: The 0.15% TB and 0.05% BBG were recommended as the better efficient treatment-assisted ILM peeling for IMH closure. For retina specialists who prefer to use ICG to assist ILM peeling, 0.05% ICG may be a good choice. However, high-quality large-scale RCTs are recommended to confirm the NMA results.
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Authors | Shan-Shan Li, Min Li, Ran You, Hui-Hui Wang, Lu Zhao, Yan-Ling Wang, Xi Chen |
Journal | International ophthalmology
(Int Ophthalmol)
Vol. 41
Issue 3
Pg. 1129-1140
(Mar 2021)
ISSN: 1573-2630 [Electronic] Netherlands |
PMID | 33392941
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
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Chemical References |
- Coloring Agents
- Indocyanine Green
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Topics |
- Basement Membrane
(surgery)
- Coloring Agents
- Epiretinal Membrane
(diagnosis, surgery)
- Humans
- Indocyanine Green
- Network Meta-Analysis
- Retina
- Retinal Perforations
(diagnosis, surgery)
- Retrospective Studies
- Treatment Outcome
- Visual Acuity
- Vitrectomy
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